Run ESMFold2 design online
ESMFold2 design — scFv CDRs + minibinders — Gradient-based binder design via ESMFold2 inversion. Pick a paper-validated target preset, choose minibinder or scFv mode, and get ranked designs with iPTM scores in one model pass.
ESMFold2 design is a free esmfold2-design tool online you can run through tools.ranomics.com on a dedicated GPU. Run it through your browser on a dedicated GPU with no install.
New accounts start with a $5 wallet balance. Pay by the second of compute. No subscriptions.
A typical result
What good looks like
Use the score legend below to read results. Each tool reports a subset of these depending on whether it does design, sequence recovery, or structure prediction.
- ipTM
- Predicted confidence in the binder to target interface. Higher is better. Aim above roughly 0.7 on a tractable target.
- pLDDT
- Per-residue confidence in the predicted fold. Higher means the model is more sure of that part of the structure.
- i_pAE and pAE
- Predicted alignment error, at the interface (i_pAE) or across the whole structure (pAE). Lower is better.
- ProteinMPNN recovery
- Fraction of native residues recovered when ProteinMPNN redesigns a known sequence on its native backbone. Higher is better; well calibrated above roughly 0.4 on diverse folds.
Ready to run it?
Sign in to open the ESMFold2 design run form. Your $5 starting balance is enough for a first job on a small target.